TCR gamma/delta 抗体 (Alexa Fluor 488)
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- 抗原 See all TCR gamma/delta products
- TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))
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适用
- 小鼠
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宿主
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仓鼠
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克隆类型
- 单克隆
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标记
- This TCR gamma/delta antibody is conjugated to Alexa Fluor 488
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应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), Intracellular Flow Cytometry (ICFC), Stimulation (St)
- 纯化方法
- The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 488 under optimal conditions.
- 克隆位点
- UC7-13D5
- 亚型
- IgG
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Protect from prolonged exposure to light. Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C
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- 抗原
- TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))
- 别名
- TCR gamma/delta (TCR gamma/delta 产品)
- 背景
- T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR γ/δ associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR γ/δ have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate TCR-γ/δ-bearing T cells in vitro, and to deplete peripheral TCR-γ/δ-bearing T cells in vivo.
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