CHEK2 抗体
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北京 101111
Quick Overview for CHEK2 抗体 (ABIN265349)
抗原
See all CHEK2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Chk2 (Q510) antibody detects endogenous levels of Chk2 protein. Species: Human. Others not tested.
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产品特性
- Synonyms: CHEK2, CHEK-2, CHK-2, RAD53, Cds1, Serine/threonine-protein kinase Chk2, CHK2checkpoint homolog
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纯化方法
- Aff - Purified
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anti-Checkpoint Kinase 2 (CHEK2) (pThr387) antibody
CHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4B7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr383) antibodyCHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pSer516) antibodyCHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibodyCHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 适用: 人, 猴, 犬 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 10G7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 适用: 人, 犬 WB, IHC, IF, IHC (p), IP, FACS 宿主: 小鼠 Monoclonal 5C4 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 适用: 人, 犬 WB, IHC, IHC (p), IP, FACS 宿主: 小鼠 Monoclonal 2H5 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyKD Validated CHEK2 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 23GB3460 unconjugated Recombinant Antibody
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应用备注
- ELISA: 1: 20000~1: 40000. WB: 1: 500~1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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限制
- 仅限研究用
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
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有效期
- 12 months
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- CHEK2 (Checkpoint Kinase 2 (CHEK2))
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别名
- CHK2
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背景
- Cell cycle events are regulated by the sequential activation and deactivation of cyclindependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved inthese processes as regulators of Cdks. Chk1 and Chk2 both function as essentialcomponents in the G2 DNA damage checkpoint by phosphorylating Cdc25C in response toDNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A,Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators bydephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown thatChk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylatedform of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation byChk1.
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UniProt
- O96017
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途径
- p53 Pathway, Apoptosis, Cell Division Cycle
抗原
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