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BCL2L1 抗体

This anti-BCL2L1 antibody is a 兔 多克隆 antibody detecting BCL2L1 in WB, IHC (p) 和 EIA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN265327
发货至: 中国

Quick Overview for BCL2L1 抗体 (ABIN265327)

抗原

See all BCL2L1 抗体
BCL2L1 (BCL2-Like 1 (BCL2L1))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This BCL2L1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • 特异性

    This antibody detects endogenous levels of Bcl-2-like 1 (Bcl-xL) protein (region surrounding Ser56).

    交叉反应 (详细)

    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

    纯度

    > 95 % pure by SDS-PAGE
  • 应用备注

    ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    BCL2L1 (BCL2-Like 1 (BCL2L1))

    别名

    Bcl-2-Like 1

    背景

    The protein encoded by this gene belongs to the Bcl2 protein family. Bcl2 family members form hetero or homodimers and act as anti or pro apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.Synonyms: BCL2L, BCL2L1, BCLX, Bcl-2-like protein 1, Bcl-x, Bcl2-L-1, bcl-xL, bcl-xS

    分子量

    approx. 26 kDa

    基因ID

    9606

    UniProt

    Q07817

    途径

    Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
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