FBXW7 抗体
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北京 101111
Quick Overview for FBXW7 抗体 (ABIN265230)
抗原
See all FBXW7 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects FBXW7, widely expressed in most tissues.
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纯化方法
- Purified
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免疫原
- Synthetic peptide dervied from the human FBXW7 protein
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应用备注
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Western Blot (1-5 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- Phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
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- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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别名
- FBXW7
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背景
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.Synonyms: Archipelago homolog, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW7, FBX30, SEL-10, SEL10, hAgo, hCDC4
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基因ID
- 55294
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NCBI登录号
- NP_001013433
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UniProt
- Q969H0
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途径
- Notch Signaling, EGFR Signaling Pathway
抗原
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