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CACNG4 抗体

CACNG4 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN265042
发货至: 中国
  • 抗原 See all CACNG4 抗体
    CACNG4 (Calcium Channel, Voltage-Dependent, gamma Subunit 4 (CACNG4))
    适用
    • 31
    • 15
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠
    宿主
    • 31
    克隆类型
    • 31
    多克隆
    标记
    • 14
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CACNG4 antibody is un-conjugated
    应用范围
    • 23
    • 15
    • 12
    • 2
    • 1
    • 1
    Western Blotting (WB)
    特异性
    This antibody reacts to CACNG4.
    纯化方法
    Purified
    免疫原
    Synthetic peptide derived from the rat calcium channel gamma4 subunit conjugated to KLH
    亚型
    IgG
    Top Product
    Discover our top product CACNG4 Primary Antibody
  • 应用备注
    Western Blot: 5- 10 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    Phosphate buffered saline with 0.08 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • 抗原
    CACNG4 (Calcium Channel, Voltage-Dependent, gamma Subunit 4 (CACNG4))
    别名
    CACNG4 (CACNG4 产品)
    别名
    CACNG4 antibody, AI413107 antibody, AW491861 antibody, calcium voltage-gated channel auxiliary subunit gamma 4 antibody, calcium channel, voltage-dependent, gamma subunit 4 antibody, CACNG4 antibody, Cacng4 antibody
    背景
    Voltage-dependent calcium channels (VDCCs) are large (>400 kDa) heteromers which contain, minimally, three core subunits alpha1, alpha2/delta, beta in a 1:1:1 stoichiometry1. Expression of VDCC gene products in Xenopus oocytes, or transfected cells shows that the alpha1 subunits contain the ion channel pore while the auxiliary alpha2/delta and beta subunits confer optimal cell surface expression and channel kinetics. Until recently, the only exception to the above paradigm was the skeletal muscle VDCC, which, in addition to the alpha1, alpha2/delta, beta core motif, also has an additional tightly associated integral membrane glycoprotein subunit termed gamma 1. Upon co-expression with the alpha1.1, alpha2/delta1, beta1a subunits of the skeletal muscle VDCC, gamma subunits alter the peak currents, and the kinetics of channel activation and inactivation with the overall effect being a normalisation of currents to those resembling the endogenous channel. Together, these results suggest that gamma subunits modulate skeletal muscle VDCCs by stabilising their conformation. The gamma 4 subunit is specifically localized in the brain, with the gamma 2 and gamma 3 subunits. It shares >60 % sequence homology with the gamma 2 and gamma 3 subunits and ~25 % sequence homology with the gamma 1 and gamma 5 subunits.Synonyms: Neuronal voltage-gated calcium channel gamma-4 subunit, Voltage-dependent calcium channel gamma-4 subunit
    基因ID
    27092
    NCBI登录号
    NP_055220
    UniProt
    Q9UBN1
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