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BAX 抗体 (Isoform beta)

This anti-BAX antibody is a 绵羊 多克隆 antibody detecting BAX in IP. Suitable for 小鼠.
产品编号 ABIN265017
发货至: 中国

Quick Overview for BAX 抗体 (Isoform beta) (ABIN265017)

抗原

See all BAX 抗体
BAX (BCL2-Associated X Protein (BAX))

适用

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小鼠

宿主

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绵羊

克隆类型

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多克隆

标记

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This BAX antibody is un-conjugated

应用范围

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Immunoprecipitation (IP)
  • 抗原表位

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    AA 172-199, Isoform beta

    特异性

    This antibody reacts to Bax-beta.

    纯化方法

    Purified

    免疫原

    Synthetic peptide corresponding to amino acids 172 to 199 of the Bax beta protein

    亚型

    IgG
  • 应用备注

    Immunoprecipitation. Will NOT detect denatured protein by Western blot.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    Phosphate buffered saline with 0.08 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • 抗原

    BAX (BCL2-Associated X Protein (BAX))

    别名

    Bax

    背景

    Bax-beta is encoded by a 1.5 kb RNA species created by the retention of intron 5 in the bax mRNA transcript. The exon4/intron5 splice junction is evolutionarily conserved and is found in both the human and mouse bax coding regions. The 630 bp intron 5 contributes 60 amino acids to the Bax-beta protein before a stop codon is encountered during translation. The Bax-beta protein is 24 kDa in size and although it contains the BH1, BH2, and BH3 domains identical to Bax, it has a unique carboxyl terminus and does not have a hydrophobic transmembrane domain (Oltvai et al., 1993). Bax-beta mRNA has been found in many mouse tissues using RT-PCR. It is found co-expressed with Bax-alpha in lung, stomach, kidney, thymus, lymph node, bone marrow, pancreas, and spleen. Bax-beta mRNA was very abundant in brain and duodenum with almost no Bax-alpha mRNA detected in these tissues (Oltvai et al., 1993).Synonyms: Apoptosis regulator BAX, BCL2-associated X protein, BCL2L4, Bcl-2-like protein 4, Bcl2-L-4

    基因ID

    12028

    NCBI登录号

    NP_031553

    UniProt

    Q07813

    途径

    p53 Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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