BAX 抗体 (Isoform beta)
Quick Overview for BAX 抗体 (Isoform beta) (ABIN265017)
抗原
See all BAX 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 172-199, Isoform beta
-
特异性
- This antibody reacts to Bax-beta.
-
纯化方法
- Purified
-
免疫原
- Synthetic peptide corresponding to amino acids 172 to 199 of the Bax beta protein
-
亚型
- IgG
-
-
-
-
应用备注
-
Immunoprecipitation. Will NOT detect denatured protein by Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
缓冲液
- Phosphate buffered saline with 0.08 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C
-
储存方法
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
-
-
- BAX (BCL2-Associated X Protein (BAX))
-
别名
- Bax
-
背景
- Bax-beta is encoded by a 1.5 kb RNA species created by the retention of intron 5 in the bax mRNA transcript. The exon4/intron5 splice junction is evolutionarily conserved and is found in both the human and mouse bax coding regions. The 630 bp intron 5 contributes 60 amino acids to the Bax-beta protein before a stop codon is encountered during translation. The Bax-beta protein is 24 kDa in size and although it contains the BH1, BH2, and BH3 domains identical to Bax, it has a unique carboxyl terminus and does not have a hydrophobic transmembrane domain (Oltvai et al., 1993). Bax-beta mRNA has been found in many mouse tissues using RT-PCR. It is found co-expressed with Bax-alpha in lung, stomach, kidney, thymus, lymph node, bone marrow, pancreas, and spleen. Bax-beta mRNA was very abundant in brain and duodenum with almost no Bax-alpha mRNA detected in these tissues (Oltvai et al., 1993).Synonyms: Apoptosis regulator BAX, BCL2-associated X protein, BCL2L4, Bcl-2-like protein 4, Bcl2-L-4
-
基因ID
- 12028
-
NCBI登录号
- NP_031553
-
UniProt
- Q07813
-
途径
- p53 Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
抗原
-