BAX 抗体 (Isoform beta)
Quick Overview for BAX 抗体 (Isoform beta) (ABIN265017)
抗原
See all BAX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - AA 172-199, Isoform beta
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特异性
 - This antibody reacts to Bax-beta.
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纯化方法
 - Purified
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免疫原
 - Synthetic peptide corresponding to amino acids 172 to 199 of the Bax beta protein
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亚型
 - IgG
 
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应用备注
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                        Immunoprecipitation. Will NOT detect denatured protein by Western blot. 
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 
                                            
限制
 - 仅限研究用
 
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缓冲液
 - Phosphate buffered saline with 0.08 % sodium azide
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储存液
 - Sodium azide
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注意事项
 - This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
 - Avoid repeated freezing and thawing.
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储存条件
 - -20 °C
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储存方法
 - The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
 
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- BAX (BCL2-Associated X Protein (BAX))
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别名
 - Bax
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背景
 - Bax-beta is encoded by a 1.5 kb RNA species created by the retention of intron 5 in the bax mRNA transcript. The exon4/intron5 splice junction is evolutionarily conserved and is found in both the human and mouse bax coding regions. The 630 bp intron 5 contributes 60 amino acids to the Bax-beta protein before a stop codon is encountered during translation. The Bax-beta protein is 24 kDa in size and although it contains the BH1, BH2, and BH3 domains identical to Bax, it has a unique carboxyl terminus and does not have a hydrophobic transmembrane domain (Oltvai et al., 1993). Bax-beta mRNA has been found in many mouse tissues using RT-PCR. It is found co-expressed with Bax-alpha in lung, stomach, kidney, thymus, lymph node, bone marrow, pancreas, and spleen. Bax-beta mRNA was very abundant in brain and duodenum with almost no Bax-alpha mRNA detected in these tissues (Oltvai et al., 1993).Synonyms: Apoptosis regulator BAX, BCL2-associated X protein, BCL2L4, Bcl-2-like protein 4, Bcl2-L-4
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基因ID
 - 12028
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NCBI登录号
 - NP_031553
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UniProt
 - Q07813
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途径
 - p53 Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
 
抗原
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