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LEF1 抗体 (AA 236-242)

This anti-LEF1 antibody is a 小鼠 单克隆 antibody detecting LEF1 in WB. Suitable for 人.
产品编号 ABIN264396
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for LEF1 抗体 (AA 236-242) (ABIN264396)

抗原

See all LEF1 抗体
LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

适用

  • 88
  • 30
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宿主

  • 63
  • 21
  • 4
  • 1
小鼠

克隆类型

  • 53
  • 36
单克隆

标记

  • 64
  • 4
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This LEF1 antibody is un-conjugated

应用范围

  • 73
  • 36
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  • 6
  • 2
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  • 1
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Western Blotting (WB)

克隆位点

3A12
  • 抗原表位

    • 9
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
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    • 1
    • 1
    • 1
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    AA 236-242

    特异性

    This antibody recognizes an epitope in amino acids 236-242 of LEF-1. This region is found within the transactivation domain of LEF-1. Epitope is missing in some splice variants.

    产品特性

    Synonyms: Lymphoid enhancer-binding factor 1, LEF-1, T cell-specific transcription factor 1-alpha,TCF1-alpha

    纯化方法

    Purified

    免疫原

    Hybridoma produced by the fusion of splenocytes from mice immunized with syntheticpeptide corresponding to amino acids 236-242 of human LEF-1 and mouse myeloma cells. Genename: LEF1

    亚型

    IgG1
  • 应用备注

    Suitable for use in Western Blot.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.08 % Sodium Azide as preservative.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store the antibody at -20 °C. Avoid repeated freezing and thawing.
    Shelf life: One year from despatch.

    有效期

    12 months
  • 抗原

    LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

    别名

    LEF1

    背景

    Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others.Synonyms: LEF-1, Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, TCF1-alpha

    基因ID

    51176

    UniProt

    Q9UJU2

    途径

    WNT signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding
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