LEF1 抗体 (AA 236-242)
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Quick Overview for LEF1 抗体 (AA 236-242) (ABIN264396)
抗原
See all LEF1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 236-242
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特异性
- This antibody recognizes an epitope in amino acids 236-242 of LEF-1. This region is found within the transactivation domain of LEF-1. Epitope is missing in some splice variants.
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产品特性
- Synonyms: Lymphoid enhancer-binding factor 1, LEF-1, T cell-specific transcription factor 1-alpha,TCF1-alpha
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纯化方法
- Purified
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免疫原
- Hybridoma produced by the fusion of splenocytes from mice immunized with syntheticpeptide corresponding to amino acids 236-242 of human LEF-1 and mouse myeloma cells. Genename: LEF1
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亚型
- IgG1
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应用备注
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Suitable for use in Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.08 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
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Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch. -
有效期
- 12 months
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- LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))
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别名
- LEF1
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背景
- Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others.Synonyms: LEF-1, Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, TCF1-alpha
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基因ID
- 51176
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UniProt
- Q9UJU2
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途径
- WNT signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding
抗原
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