The antibody detects endogenous levels of Synaptotagmin only when phosphorylated at threonine 202.
纯化方法
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
免疫原
Synaptotagmin (phospho Thr202) antibody was raised against a peptide sequence around phosphorylation site of threonine 202 (R-K-T (p)-L-N) derived from Human Synaptotagmin.
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse.