The antibody detects endogenous level of Ezrin only when phosphorylated at tyrosine 478.
纯化方法
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
免疫原
Ezrin (phospho Tyr478) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 478 (P-V-Y (p)-E-P) derived from Human Ezrin.
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.