The antibody detects endogenous levels of Claudin 7 only when phosphorylated at tyrosine 210.
纯化方法
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
免疫原
Claudin 7 (phospho Tyr210) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 210 (S-K-E-Y (p)-V) derived from Human Claudin 7.
Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells.