-
- 抗原 See all SIGLEC12 抗体
- SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This SIGLEC12 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- Antibody is purified by peptide affinity chromatography method.
- 免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SIGLEC12.
- Top Product
- Discover our top product SIGLEC12 Primary Antibody
-
anti-Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12) (AA 503-595) antibody
SIGLEC12 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D1 unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12) (AA 27-141) antibodySIGLEC12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12) (AA 20-210) antibodySIGLEC12 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12) antibodySIGLEC12 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12) (AA 1-595) antibodySIGLEC12 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12) (AA 38-87) antibodySIGLEC12 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12) (AA 110-159) antibodySIGLEC12 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12) (AA 218-267) antibodySIGLEC12 适用: 人, Cow, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12) (AA 20-210) antibodySIGLEC12 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12) (AA 22-218) antibodySIGLEC12 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- SIGLEC12 antibody can be used for detection of SIGLEC12 by ELISA at 1:1562500. SIGLEC12 antibody can be used for detection of SIGLEC12 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- 注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store SIGLEC12 antibody at -20 °C.
-
- 抗原
- SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))
- 别名
- SIGLEC12 (SIGLEC12 产品)
- 别名
- S2V antibody, SIGLECL1 antibody, SLG antibody, Siglec-XII antibody, sialic acid binding Ig like lectin 12 (gene/pseudogene) antibody, sialic acid binding Ig like lectin 12 antibody, sialic acid binding Ig-like lectin 12 antibody, SIGLEC12 antibody
- 背景
- Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. SIGLEC12, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.Western blots using four different antibodies against four unique regions of this protein target confirm the same apparent molecular weight in our tests.Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
- 分子量
- 63 kDa
- 基因ID
- 89858
- NCBI登录号
- NP_443729
- UniProt
- Q96PQ1
-
You are here:
