C-Type Lectin Domain Family 4, Member M (CLEC4M) 抗体
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- 抗原 See all C-Type Lectin Domain Family 4, Member M (CLEC4M) 抗体
- C-Type Lectin Domain Family 4, Member M (CLEC4M)
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- Antibody is purified by peptide affinity chromatography method.
- 免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CLEC4M.
- Top Product
- Discover our top product CLEC4M Primary Antibody
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anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 242-399) antibody
CLEC4M 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 237-399) antibodyCLEC4M 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 8A1B3 unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 271-320) antibodyCLEC4M 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 238-382) antibodyCLEC4M 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) antibodyCLEC4M 适用: 人 IHC, FACS 宿主: 兔 Chimeric 16E7 unconjugated Recombinant Antibody
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 285-394) antibodyCLEC4M 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G1 unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 51-100) antibodyCLEC4M 适用: 人, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (N-Term) antibodyCLEC4M 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 285-394) antibodyCLEC4M 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 143-192) antibodyCLEC4M 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- CLEC4M antibody can be used for detection of CLEC4M by ELISA at 1:312500. CLEC4M antibody can be used for detection of CLEC4M by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- 注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store CLEC4M antibody at -20 °C.
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- 抗原
- C-Type Lectin Domain Family 4, Member M (CLEC4M)
- 别名
- CLEC4M (CLEC4M 产品)
- 别名
- CD209L antibody, CD299 antibody, DC-SIGN2 antibody, DC-SIGNR antibody, DCSIGNR antibody, HP10347 antibody, L-SIGN antibody, LSIGN antibody, CD209B antibody, C-type lectin domain family 4 member M antibody, CLEC4M antibody
- 背景
- CLEC4M is a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835, often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.This gene encodes a type II integral membrane protein that is 77 % identical to CD209 antigen, a HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
- 分子量
- 30 kDa
- 基因ID
- 10332
- NCBI登录号
- NP_999842
- UniProt
- Q9H2X3
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