FJHN,Hepatocyte nuclear factor 1 beta,Hepatocyte nuclear factor 1-beta,HNF 1B,HNF 2,HNF-1-beta,HNF-1B,HNF1 beta,HNF1 homeobox B,HNF1B,HNF1B,HNF1beta,HNF2,Homeoprotein LF B3,Homeoprotein LFB3,HPC11,LF B3,LFB3,MODY 5,MODY5,TCF 2,TCF 2 protein,TCF-2,TCF2,TCF2 protein,Transcription factor 2,Transcription factor 2 hepatic,Variant hepatic nuclear factor 1,Variant hepatic nuclear factor,VHNF 1,vHNF1,This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.