-
- 抗原 See all Cullin 4A (CUL4A) 抗体
- Cullin 4A (CUL4A)
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This Cullin 4A antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 纯化方法
- Antigen affinity purification
- 免疫原
- Synthetic peptide of human CUL4A
- 亚型
- IgG
- Top Product
- Discover our top product CUL4A Primary Antibody
-
anti-Cullin 4A (CUL4A) (AA 1-759) antibody
CUL4A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) antibodyCUL4A 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) antibodyCUL4A 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) (AA 1-100) antibodyCUL4A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) (AA 1-100) antibodyCUL4A 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 3H3 unconjugated
anti-Cullin 4A (CUL4A) (AA 1-759) antibodyCUL4A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) antibodyCUL4A 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Cullin 4A (CUL4A) (AA 31-60), (N-Term) antibodyCUL4A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB33954 unconjugated
anti-Cullin 4A (CUL4A) (Middle Region) antibodyCUL4A 适用: 人, 小鼠, 大鼠, 马, 兔, 犬, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) antibodyCUL4A 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 注意事项
- Avoid freeze / thaw cycles.
- 储存条件
- -20 °C/-80 °C
- 储存方法
- Store at -20°C (regular) and -80°C (long term).
-
- 抗原
- Cullin 4A (CUL4A)
- 别名
- CUL4A (CUL4A 产品)
- 别名
- zgc:64071 antibody, CUL4A antibody, 2810470J21Rik antibody, AW495282 antibody, RGD1563853 antibody, cullin 4A antibody, CUL4A antibody, cul4a antibody, Cul4a antibody
- 背景
-
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins.Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication.
- 分子量
- Calculated MW: 88 kDa
-
You are here:
