CD14 抗体 (APC)
Quick Overview for CD14 抗体 (APC) (ABIN238454)
抗原
See all CD14 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应 (详细)
- Species reactivity (tested):Human, Non-Human Primates
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纯化方法
- Size-exclusion chromatography
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免疫原
- A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria
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亚型
- IgG1
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应用备注
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Suitable for Flow Cytometry analysis of human blood cells using 10 m l reagent / 100 m l of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS, pH 7.4 with 15 mM sodium azide as preservative and 0.2 % (w/v) high-grade BSA (protease free) as a stabilizer
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
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Store the antibody in the dark at 2-8 °C. Do Not freeze! Avoid prolonged exposure to light.
Shelf Life: One year from despatch. -
有效期
- 12 months
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- CD14
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别名
- CD14
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背景
- CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor, it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipo-polysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipo-polysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.Synonyms: Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein
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UniProt
- P08571
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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