Benzo[a]pyrenediol Epoxide 抗体
BPDE
适用: 化学剂
IA, IP
宿主: 小鼠
Monoclonal
8E11
unconjugated
(3 references)-
- 抗原 See all Benzo[a]pyrenediol Epoxide (BPDE) products
- Benzo[a]pyrenediol Epoxide (BPDE)
- 适用
- 化学剂
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Benzo[a]pyrenediol Epoxide antibody is un-conjugated
- 应用范围
- Immunoassay (IA), Immunoprecipitation (IP)
- 过滤
- 0.2 μm filtered
- 克隆位点
- 8E11
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- 应用备注
- The monoclonal antibody 8E11 can be used for immuno purification and for immuno assays as detector.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Immunohistochemical analysis of polycyclic aromatic hydrocarbon-DNA adducts in breast tumor tissue." in: Cancer letters, Vol. 154, Issue 2, pp. 143-9, (2000) (PubMed).
: "A sensitive color ELISA for detecting polycyclic aromatic hydrocarbon-DNA adducts in human tissues." in: Mutation research, Vol. 359, Issue 3, pp. 171-7, (1996) (PubMed).
: "Monoclonal antibodies to DNA modified by a benzo[a]pyrene diol epoxide." in: Carcinogenesis, Vol. 5, Issue 3, pp. 373-7, (1984) (PubMed).
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: "Immunohistochemical analysis of polycyclic aromatic hydrocarbon-DNA adducts in breast tumor tissue." in: Cancer letters, Vol. 154, Issue 2, pp. 143-9, (2000) (PubMed).
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- 抗原
- Benzo[a]pyrenediol Epoxide (BPDE)
- Abstract
- BPDE 产品
- 物质类
- Chemical
- 背景
- A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representitive PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic. The monoclonal antibody 8E11 recognizes free BPDE and DNA adducts.
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