(5 references)-
- 抗原 See all BPDE-DNA products
- BPDE-DNA (Benzo[a]pyrenediol Epoxide Modified DNA (BPDE-DNA))
- 适用
- 化学剂
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This BPDE-DNA antibody is un-conjugated
-
应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoassay (IA), Flow Cytometry (FACS)
- 过滤
- 0.2 μm filtered
- 克隆位点
- 5D11
-
-
- 应用备注
- For immunohistochemistry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
- 限制
- 仅限研究用
-
- 缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
-
-
: "Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri." in: The Journal of clinical investigation, Vol. 117, Issue 12, pp. 3971-8, (2007) (PubMed).
: "Selective immunoclean-up followed by liquid chromatography for the monitoring of a biomarker of exposure to polycyclic aromatic hydrocarbons in urine at the ng l-1 level." in: Journal of chromatography. A, Vol. 1120, Issue 1-2, pp. 185-93, (2006) (PubMed).
: "Polycyclic aromatic hydrocarbon-DNA adducts in prostate cancer." in: Cancer research, Vol. 64, Issue 24, pp. 8854-9, (2004) (PubMed).
: "Immunohistochemical detection of polycyclic aromatic hydrocarbon-DNA damage in human blood vessels of smokers and non-smokers." in: Atherosclerosis, Vol. 140, Issue 2, pp. 325-31, (1999) (PubMed).
: "Monoclonal antibodies to DNA modified by a benzo[a]pyrene diol epoxide." in: Carcinogenesis, Vol. 5, Issue 3, pp. 373-7, (1984) (PubMed).
-
: "Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri." in: The Journal of clinical investigation, Vol. 117, Issue 12, pp. 3971-8, (2007) (PubMed).
-
- 抗原
- BPDE-DNA (Benzo[a]pyrenediol Epoxide Modified DNA (BPDE-DNA))
- Abstract
- BPDE-DNA 产品
- 物质类
- Chemical
- 背景
- A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representative PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic. The monoclonal antibody 5D11 recognizes BPDE-I-DNA (PAH-DNA). Immunogen BPDE-I-DNA complexed with methylated BSA
-
You are here:
