CD14 抗体
(2 references)Our Local Distributor
北京 101111
Quick Overview for CD14 抗体 (ABIN2192076)
抗原
See all CD14 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
过滤
- 0.2 μm filtered
-
-
anti-CD14 (CD14) (AA 20-214) antibody
CD14 适用: 人, 小鼠 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal 4B4F12 unconjugated
anti-CD14 (CD14) (AA 20-214) antibodyCD14 适用: 人 IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 1H5D8 unconjugated
anti-CD14 (CD14) antibodyCD14 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 1A3B6 unconjugated
anti-CD14 (CD14) (AA 20-345) antibodyCD14 适用: 人 FACS, WB, IHC, IF, ELISA 宿主: 小鼠 Monoclonal 14G1F3 unconjugated
anti-CD14 (CD14) (AA 25-148) antibodyCD14 适用: 人 FACS, WB, IHC, ISt, StM 宿主: 小鼠 Monoclonal LPSR-2385 unconjugated
anti-CD14 (CD14) (AA 230-345) antibodyCD14 适用: 人 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal 1D1F8 unconjugated
anti-CD14 (CD14) (AA 54-83), (N-Term) antibodyCD14 适用: 人 FACS, WB, IF, IHC (p) 宿主: 兔 Polyclonal RB14105 unconjugated
anti-CD14 (CD14) (AA 201-300) antibodyCD14 适用: 人, 小鼠, 大鼠, 绵羊, 犬, 兔 WB, ELISA, ICC, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-CD14 (CD14) (Internal Region) antibodyVerified CD14 适用: 人 FACS, WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-CD14 (CD14) (AA 25-148) antibodyCD14 适用: 人 WB, IHC, ISt, StM 宿主: 小鼠 Monoclonal LPSR-2397 unconjugated
-
-
应用备注
- For flow cytometry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For inhibition of biological activity in vitro dilutions have to be made according to the amounts of human sCD14 to be inactivated.
-
限制
- 仅限研究用
-
-
-
缓冲液
- PBS, containing 0.1 % bovine serum albumin.
-
储存条件
- 4 °C
-
储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
-
有效期
- 12 months
-
-
-
: "Human CD14 is an efficient target for recombinant immunoglobulin vaccine constructs that deliver T cell epitopes." in: Journal of leukocyte biology, Vol. 77, Issue 3, pp. 303-10, (2005) (PubMed).
: "Peptidoglycan primes for LPS-induced release of proinflammatory cytokines in whole human blood." in: Shock (Augusta, Ga.), Vol. 16, Issue 3, pp. 178-82, (2001) (PubMed).
-
: "Human CD14 is an efficient target for recombinant immunoglobulin vaccine constructs that deliver T cell epitopes." in: Journal of leukocyte biology, Vol. 77, Issue 3, pp. 303-10, (2005) (PubMed).
-
- CD14
-
别名
- CD14
-
背景
- The monoclonal antibody 18D11 recognizes human monocyte marker CD14, a 53 kDa glycoprotein. CD14 is a glycophosphatidylinositol-linked protein, which is part of the LPS receptor complex. CD14 binds lipopolysaccharide (LPS) and as such, acts as a pattern recognition receptor (PRR). CD14 has also been suggested to mediate phagocytosis of bacteria an apoptotic cells. CD14 is involved in the endotoxin mediated release of Tumor Necrosis Factor-alpha by monocytic cells. CD14 is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is present at low density on a subpopulation granulocytes and activated or transformed B-cells. The monoclonal antibody 18D11 reacts with both soluble and membrane CD14. The monoclonal antibody 18D11 is useful for inhibition of biological activity of sCD14, it inhibits LPS induced TNF production. The monoclonal antibody is cross reactive with pig CD14. Together with a C5a neutralizing monoclonal antibody, 18D11 blocks sepsis in a pig model.
-
途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
-
