BPI 抗体
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- 抗原 See all BPI 抗体
- BPI (Bactericidal/Permeability Increasing Protein (BPI))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This BPI antibody is un-conjugated
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应用范围
- Immunoassay (IA)
- 过滤
- 0.2 μm filtered
- 克隆位点
- 4H5
- Top Product
- Discover our top product BPI Primary Antibody
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anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 320-457) antibody
BPI 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 140-250) antibodyBPI 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 149-362) antibodyBPI 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (Internal Region) antibodyBPI 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) antibodyBPI 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 293-324) antibodyBPI 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB17726 unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 301-331), (Middle Region) antibodyBPI 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) antibodyBPI 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (Internal Region) antibodyVerified BPI 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 248-487) antibodyBPI 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- The monoclonal antibody 4H5 can be used for immuno assays both as coating and as detector.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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- 抗原
- BPI (Bactericidal/Permeability Increasing Protein (BPI))
- 别名
- Bactericidal Permeability Increasing Protein (BPI 产品)
- 别名
- 9230105K17Rik antibody, Bpifd1 antibody, BPIFD1 antibody, rBPI antibody, bpi antibody, bpi.L antibody, lbp antibody, bactericidal/permeability-increasing protein antibody, bactericidal permeablility increasing protein antibody, bactericidal/permeability-increasing protein S homeolog antibody, BPI antibody, Bpi antibody, bpi.S antibody
- 背景
- The monoclonal antibody 4H5 reacts specifically with full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI). The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin. The monoclonal antibody 4H5 recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.
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