S1A9 (AA 2-114) 抗体 (Biotin)

Background: S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transfering arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn2+ which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect, regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.

Aliases: Leukocyte L1 complex heavy chain antibody, 60B8AG antibody, CAGB antibody, Calgranulin B antibody, Calgranulin-B antibody, Calprotectin L1H subunit antibody, CFAG antibody, CGLB antibody, Cystic fibrosis antigen B antibody, L1AG antibody, Leukocyte L1 complex heavy chain antibody, LIAG antibody, MAC387 antibody, MIF antibody, Migration inhibitory factor related protein 14 antibody, Migration inhibitory factor-related protein 14 antibody, MRP 14 antibody, MRP-14 antibody, MRP14 antibody, Myeloid-related protein 14 antibody, NIF antibody, OTTHUMP00000015331 antibody, p14 antibody, Protein S100-A9 antibody, S100 A9 antibody, S100 calcium binding protein A9 antibody, S100 calcium binding protein A9 calgranulin B antibody, S100 calcium-binding protein A9 antibody, S100A9 antibody, S10A9_HUMAN antibody