Early Protein 抗体 (FITC)
适用: Human Papillomavirus 16 (HPV-16)
ELISA, WB
宿主: 兔
Polyclonal
FITC
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- 抗原
- Early Protein
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适用
- Human Papillomavirus 16 (HPV-16)
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- FITC
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应用范围
- ELISA, Western Blotting (WB)
- 纯化方法
- Caprylic Acid Ammonium Sulfate Precipitation
- 免疫原
- Recombinant human papillomavirus type 16 Protein E6 protein
- 亚型
- IgG
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- 应用备注
- Optimal working concentration should be determinde by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 0.03 % Proclin 300, 53 % Glycerol, 0.01 M PBS, pH 7.4
- 储存液
- ProClin
- 注意事项
- This product contains ProClinTM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze.
- 储存条件
- -20 °C/-80 °C
- 储存方法
- Upon delivery aliquot and store at -20 °C or -80 °C.
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- 抗原
- Early Protein
- 别名
- Protein E6
- 别名
- early protein 6 antibody, E6 antibody
- 物质类
- Viral Protein
- 背景
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Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
Synonyms: E6 - UniProt
- P03126
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