BAX 抗体 (N-Term)
Quick Overview for BAX 抗体 (N-Term) (ABIN1888187)
抗原
See all BAX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - N-Term
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纯化方法
 - Ion exchange chromatography purified
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免疫原
 - Peptide corresponding to 16 amino acids near the amino-terminus of human Bax.
 
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限制
 - 仅限研究用
 
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状态
 - Liquid
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缓冲液
 - PBS containing 0.02 % sodium azide.
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储存液
 - Sodium azide
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注意事项
 - WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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注意事项
 - Avoid freezing and thawing repeatly.
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储存条件
 - 4 °C/-20 °C
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储存方法
 - Store at 4 °C for short term use.Store at -20 °C for long term preservation.
 
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                                            : "Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway."    in: Molecular biology reports, Vol. 40, Issue 1, pp. 129-39, (2012)         (PubMed).        
 
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                                            : "Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway."    in: Molecular biology reports, Vol. 40, Issue 1, pp. 129-39, (2012)         (PubMed).        
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- BAX (BCL2-Associated X Protein (BAX))
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别名
 - Bax
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背景
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                        Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells.Disruption of this process has been implicated in a variety of diseases such as cancer.The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death.Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli.It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability.
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途径
 - p53 Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
 
抗原
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