Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
交叉反应 (详细)
RBM35A antibody is predicted to not cross-react with other RBM35/ESRP family members. At least five isoforms of RBM35A are known to exist, this antibody will detect all five.
纯化方法
Affinity chromatography purified via peptide column
免疫原
18 amino acid peptide near the amino terminus of human RBM35A.
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注意事项
Avoid freezing and thawing repeatly.
储存条件
4 °C/-20 °C
储存方法
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
抗原
ESRP1
(Epithelial Splicing Regulatory Protein 1 (ESRP1))
RBM35A, also known as ESRP1, is a mRNA splicing factor that with its related protein RBM35B (ESRP2) are coordinators of an epithelial cell-type-specific splicing program.RBM35A contains three putative RNA recognition motifs and acts by directly binding specific sequences in mRNAs.RBM35A is involved in posttranscriptional regulation of a number of genes such as FGFR2, CD44, CTNND1, and ENAH by exerting a differential effect on protein translation via 5' UTRs of mRNAs.Other recent studies have shown that RMB35A may also act as a novel tumor suppressor. Synonyms: RNA-binding motif protein 35A, RMB35A, Epithelial splicing regulatory protein 1, ESRP1