THEM4 抗体 (Center)
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- 抗原 See all THEM4 抗体
- THEM4 (Thioesterase Superfamily Member 4 (THEM4))
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抗原表位
- Center
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This THEM4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- THEM4 antibody was raised against an 18 amino acid peptide near the center of human THEM4.
- Top Product
- Discover our top product THEM4 Primary Antibody
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anti-Thioesterase Superfamily Member 4 (THEM4) (AA 1-240) antibody
THEM4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Thioesterase Superfamily Member 4 (THEM4) (AA 37-150) antibodyTHEM4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Thioesterase Superfamily Member 4 (THEM4) (Center) antibodyTHEM4 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
- 注意事项
- Avoid freezing and thawing repeatly.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- 抗原
- THEM4 (Thioesterase Superfamily Member 4 (THEM4))
- 别名
- THEM4 (THEM4 产品)
- 别名
- THEM4 antibody, CTMP antibody, 2700077M13Rik antibody, 4921507I02Rik antibody, RGD1304723 antibody, thioesterase superfamily member 4 antibody, thioesterase superfamily member 4 L homeolog antibody, THEM4 antibody, them4 antibody, Them4 antibody, them4.L antibody
- 背景
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THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells.Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer.Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase.Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.
Synonyms: Thioesterase superfamily member 4, Carboxy-terminal modulator protein, CTMP - NCBI登录号
- NP_444283
- 途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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