PHAP I 抗体 (C-Term)
适用: 人, 小鼠, 大鼠
WB, ELISA, IHC
宿主: 兔
Polyclonal
unconjugated
-
- 抗原 See all PHAP I products
- PHAP I
- 抗原表位
- C-Term
- 适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This PHAP I antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应 （详细）
- This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- PHAP I antibody was raised with a Synthetic peptide corresponding to amino acids at carboxy terminus of human PHAP I.
-
-
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
- 注意事项
- Avoid freezing and thawing repeatly.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
-
- 抗原
- PHAP I
- Abstract
- PHAP I 产品
- 背景
-
Apoptosis is related to many diseases and development.Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators.Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9.Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis.The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis.PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway.PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
- 分子量
- 32 kDa
- UniProt
- P39687
-
You are here:
