WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
注意事项
Avoid freezing and thawing repeatly.
储存条件
4 °C/-20 °C
储存方法
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
PNAS4 is a highly conserved protein that shares high homology from plants to animals.It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4.PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549.PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway.Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine.At least two isoforms of PNAS4 are known to exist. Synonyms: PPPDE peptidase domain containing 1, CGI-146, FAM152A