TMEM59L
适用: 人
WB, IF (p), IF (cc)
宿主: 兔
Polyclonal
FITC
限制
仅限研究用
状态
Liquid
缓冲液
PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
注意事项
Avoid freezing and thawing repeatly.
储存条件
4 °C/-20 °C
储存方法
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
LOC719572 antibody, BSMAP antibody, C19orf4 antibody, 5330410G16Rik antibody, RGD1305557 antibody, transmembrane protein 59 like antibody, transmembrane protein 59-like antibody, TMEM59L antibody, Tmem59l antibody
背景
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis.TMEM59L is a type I membrane glycoprotein that is expressed in the brain.A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding. Synonyms: Transmembrane protein 59L, brain-specific membrane-anchored protein, BSMAP