HUWE1 抗体 (C-Term)
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- 抗原 See all HUWE1 抗体
- HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))
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抗原表位
- C-Term
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HUWE1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- 19 amino acid peptide from near the carboxy terminus of human ARF-BP1.
- Top Product
- Discover our top product HUWE1 Primary Antibody
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anti-HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) (C-Term) antibody
HUWE1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) antibodyHUWE1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) (AA 4281-4374) antibodyHUWE1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) (C-Term) antibodyHUWE1 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) (C-Term) antibodyHUWE1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
- 注意事项
- Avoid freezing and thawing repeatly.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- 抗原
- HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))
- 别名
- ARF-BP1 (HUWE1 产品)
- 别名
- ARF-BP1 antibody, HECTH9 antibody, HSPC272 antibody, Ib772 antibody, LASU1 antibody, MULE antibody, URE-B1 antibody, UREB1 antibody, 5430439H10Rik antibody, AU041296 antibody, Arf-bp1 antibody, C430014N20Rik antibody, C80292 antibody, Gm1718 antibody, Mule antibody, Ureb1 antibody, HUWE1 antibody, si:dkey-242a8.2 antibody, Huwe1 antibody, mule antibody, ib772 antibody, lasu1 antibody, ureb1 antibody, hecth9 antibody, arf-bp1 antibody, hspc272 antibody, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase antibody, HECT, UBA and WWE domain containing 1 antibody, E3 ubiquitin-protein ligase HUWE1 antibody, HUWE1 antibody, Huwe1 antibody, huwe1 antibody, LOC100123214 antibody, LOC100380641 antibody
- 背景
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The ARF tumor suppressor is a critical regulator of p53 stability.In addition to p53, ARF1 binds to other proteins such as MDM2 and ARF-BP1, a large protein containing HECT, UBA and WWE motifs.ARF-BP1 directly binds and ubiquitinates p53, this activity is inhibited by ARF, indicating that ARF-BP1 is a critical mediator of the p53-dependent and p53-independent tumor suppressor functions of ARF.ARF-BP1 can also catalyze the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involved in DNA damage-induced apoptosis.Elimination of ARF-BP1 expression by RNA interference stabilized Mcl-1 protein, resulting in an attenuation of apoptosis induced by DNA-damage agents.
Synonyms: ARF binding protein 1, HECT, UBA and WWE domain containing 1, HUWE1, Mcl-1 ubiquitin ligase E3, Mule - NCBI登录号
- NP_113584
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