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Tuberin 抗体 (AA 1397-1426)

Cited in 3+ publications. This 兔 多克隆 anti-Tuberin antibody (Clone RB42388) specifically detects Tuberin in WB 和 IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN1881946
发货至: 中国
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Quick Overview for Tuberin 抗体 (AA 1397-1426) (ABIN1881946)

抗原

See all Tuberin (TSC2) 抗体
Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

适用

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宿主

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克隆类型

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多克隆

标记

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This Tuberin antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB42388
  • 抗原表位

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    AA 1397-1426

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This TSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1397-1426 amino acids from the Central region of human TSC2.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. IHC-P: 1:25

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • Dántola, Denofrio, Zurbano, Gimenez, Ogilby, Lorente, Thomas: "Mechanism of photooxidation of folic acid sensitized by unconjugated pterins." in: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, Vol. 9, Issue 12, pp. 1604-12, (2010) (PubMed).

    Larson, Liu, Stevens, Li, Li, Evers, Gao: "Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1." in: The Journal of biological chemistry, Vol. 285, Issue 32, pp. 24987-98, (2010) (PubMed).

    Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

  • 抗原

    Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

    别名

    TSC2

    背景

    Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

    分子量

    200608

    NCBI登录号

    NP_000539, NP_001070651, NP_001107854

    UniProt

    P49815

    途径

    RTK signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus
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