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- 抗原 See all TGFBR1 抗体
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
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抗原表位
- AA 145-172
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TGFBR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- B, Pig, Rat
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This TGFBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-172 amino acids from the Central region of human TGFBR1.
- 克隆位点
- RB43638
- 亚型
- Ig Fraction
- Top Product
- Discover our top product TGFBR1 Primary Antibody
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anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 30-125) antibody
TGFBR1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 50-63) antibodyVerified TGFBR1 适用: 人, 大鼠 WB, ELISA, IHC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (pSer165) antibodyTGFBR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 157-244) antibodyTGFBR1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) antibodyTGFBR1 适用: 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 34-124) antibodyTGFBR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (AA 162-403) antibodyTGFBR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) antibodyTGFBR1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (Tyr159) antibodyTGFBR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Transforming Growth Factor, beta Receptor 1 (TGFBR1) (Internal Region) antibodyTGFBR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:2000. WB: 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
- 别名
- TGFBR1 (TGFBR1 产品)
- 别名
- AAT5 antibody, ACVRLK4 antibody, ALK-5 antibody, ALK5 antibody, LDS1A antibody, LDS2A antibody, MSSE antibody, SKR4 antibody, TGFR-1 antibody, aat5 antibody, acvrlk4 antibody, alk-5 antibody, alk5 antibody, lds1a antibody, lds2a antibody, skr4 antibody, tgfr-1 antibody, TGFBR1 antibody, x-trr1 antibody, AU017191 antibody, Alk-5 antibody, TbetaR-I antibody, TbetaRI antibody, Alk5 antibody, Skr4 antibody, Tgfr-1 antibody, tbetaR-I antibody, tgfbr1 antibody, zgc:123263 antibody, transforming growth factor beta receptor 1 antibody, transforming growth factor beta receptor I antibody, transforming growth factor beta receptor I S homeolog antibody, transforming growth factor, beta receptor I antibody, transforming growth factor, beta receptor 1 antibody, transforming growth factor, beta receptor 1 a antibody, TGFBR1 antibody, tgfbr1 antibody, tgfbr1.S antibody, Tgfbr1 antibody, tgfbr1a antibody
- 背景
- Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
- 分子量
- 55960
- NCBI登录号
- NP_001124388, NP_004603
- UniProt
- P36897
- 途径
- Growth Factor Binding
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