LEF1 抗体
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北京 101111
Quick Overview for LEF1 抗体 (ABIN187758)
抗原
See all LEF1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Antibody reacts with human LEF-1, TCF-1, TCF-3, and TCF-4 Species Reactivity: Human, other species not tested.
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免疫原
- Full length LEF
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anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (AA 100-399) antibody
LEF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (AA 331-399) antibodyLEF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (AA 1-399) antibodyLEF1 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 3H5 unconjugated
anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (Internal Region) antibodyVerified LEF1 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (AA 33-138) antibodyLEF1 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 1A4B11 unconjugated
anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (AA 14-123) antibodyLEF1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 5A3 unconjugated
anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (AA 75-216) antibodyLEF1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (AA 33-138) antibodyLEF1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (AA 10-37), (N-Term) antibodyLEF1 适用: 人 WB, IF 宿主: 兔 Polyclonal RB31989 unconjugated
anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (Internal Region) antibodyLEF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot: Use at 1-5 µg/ml The optimal dilution for a specific application should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 1 mg/ml purified IgG in PBS with 0.02% sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))
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别名
- LEF1
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背景
- Lymphoid Enhancer Factor - 1 is a transcription factor of the High Mobility Group of DNA binding proteins. It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF-1, TCF-1, TCF-3, and TCF-4) These factors play a crucial role in WNT/Wingless signaling, a transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also involved in the genesis of some cancers, including colon cancer, melanoma, and breast cancer. LEF-1 is expressed during development in many differentiating tissues, and in a few tissues after birth. LEF-1 expression is required for proper development of breast, teeth, hair, whiskers, and the trigeminal nerve. It is redundant with TCF-1 (T Cell Factor-1) for correct development of T lymphocytes in the thymus. LEF-1 is a 399 amino acid protein that appears as a cluster of polypeptides ranging in size between 55-57 kD on SDS-PAGE gels. Alternative splice forms of LEF-1 and other LEF/TCF family members have been identified, but the expression pattern and relative abundance of these alternative forms have not been well studied. They may appear on Western blots as smaller immunoreactive forms.
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途径
- WNT signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding
抗原
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