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DYNLL1 抗体 (Cytoplasmic)

DYNLL1 适用: 人, 小鼠 WB, FACS 宿主: 大鼠 Monoclonal 10D6 unconjugated
产品编号 ABIN187402
发货至: 中国
  • 抗原 See all DYNLL1 抗体
    DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))
    抗原表位
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic
    适用
    • 38
    • 27
    • 27
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    人, 小鼠
    宿主
    • 35
    • 3
    大鼠
    克隆类型
    • 26
    • 12
    单克隆
    标记
    • 18
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This DYNLL1 antibody is un-conjugated
    应用范围
    • 19
    • 12
    • 9
    • 4
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    特异性
    Recognizes human and mouse DLC1. Does not cross-react with DLC2. Species Reactivity: Mouse and human. Others not tested.
    免疫原
    Recombinant mouse DLC1 [LC8, PIN].
    克隆位点
    10D6
    亚型
    IgM
    Top Product
    Discover our top product DYNLL1 Primary Antibody
  • 应用备注
    Flow Cytometry. Western blot: use at least a 1:1,000 dilution. The optimal dilution for a specific application should be determined by the researcher.
    限制
    仅限研究用
  • 浓度
    1 mg/mL.
    缓冲液
    100 µg affinity purified antibody in PBS containing 0.02% sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • 抗原
    DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))
    别名
    DYNLL1 (DYNLL1 产品)
    别名
    DLC1 antibody, DLC8 antibody, DNCL1 antibody, DNCLC1 antibody, LC8 antibody, LC8a antibody, PIN antibody, hdlc1 antibody, dynll2 antibody, wu:fd56c09 antibody, zgc:73406 antibody, Dlc8 antibody, Dnclc1 antibody, Pin antibody, 8kDLC antibody, lc8 antibody, dlc1 antibody, dlc8 antibody, lc8a antibody, dncl1 antibody, dnclc1 antibody, dynll1a antibody, MGC68763 antibody, CDLC2 antibody, dynll1 antibody, dynll1b antibody, pin antibody, MGC89636 antibody, dynein light chain LC8-type 1 antibody, dynein, light chain, LC8-type 1 antibody, dynein light chain LC8-type 1 S homeolog antibody, dynein light chain LC8-type 1 L homeolog antibody, Dynein light chain 1, cytoplasmic antibody, DYNLL1 antibody, dynll1 antibody, Dynll1 antibody, dynll1.S antibody, dynll1.L antibody, dlc-1 antibody
    背景
    The 10 kDa dynein light chain 1 (DLC1, LC8), also known as neuronal nitric oxide synthase inhibitory protein or PIN (protein inhibitor of nNOS), is a component of cytoplasmic dynein, which is involved in the minus end-directed movement of organelles along microtubules. It is a highly conserved protein that is associated with the microtubular dynein motor complex by its binding to dynein intermediate chain (DIC). This allows DLC1 to act as a cargo protein, hooking many different proteins to the dynein motor complex. Binding of the BH3-only protein, Bim, to DLC1 also controls its pro-apoptotic activity. In healthy cells, most Bim molecules are sequestered from Bcl-2 and its homologs by DLC1 mediated binding to the dynein motor complex. Certain apoptotic signals, such as cytokine withdrawal or deregulated calcium flux, induces the release of Bim and DLC1 from the dynein motor complex. This allows Bim and DLC1 to translocate and bind to Bcl-2 and its homologs, thus neutralizing their anti-apoptotic activity.
    途径
    M Phase, Tube Formation, Positive Regulation of Endopeptidase Activity
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