IGFBP5 抗体
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北京 101111
Quick Overview for IGFBP5 抗体 (ABIN181655)
抗原
See all IGFBP5 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects Insulin-like Growth Factor Binding Protein 5.
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纯化方法
- Immunoaffinity Chromatography
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免疫原
- Highly pure (> 98 %) recombinant human IGF-BP5
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anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 68-167) antibody
IGFBP5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) antibodyIGFBP5 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 25-271) antibodyIGFBP5 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) antibodyIGFBP5 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 101-200) antibodyIGFBP5 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 27-248) antibodyIGFBP5 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 27-248) antibodyIGFBP5 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 87-121) antibodyIGFBP5 适用: 人 WB 宿主: 兔 Polyclonal RB54635 unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 1-272) antibodyIGFBP5 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 111-160) antibodyIGFBP5 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 兔, 绵羊, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Indirect ELISA: To detect hIGF-BP5 (using 100 μL/well antibody solution) a concentration of0.5-2.0 μg/mL of this antibody is required. In conjunction with compatible secondaryreagents, it allows the detection of at least 0.2-0.4 ng/well of recombinant hIGF-BP5. Sandwich ELISA: To detect hIGF-BP5 (using 100 μL/well antibody solution) a concentrationof 0.5-2.0 μg/mL of this antibody is required. In conjunction with Biotinylated Anti-HumanIGF-BP5 (ABIN181653 or ABIN181654) as a detection antibody, it allows the detection ofat least 0.2-0.4 ng/well of recombinant hIGF-BP5. Western blot: To detect hIGF-BP5 this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit forrecombinant hIGF-BP5 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS, pH 7.2
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the lyophilized antibody at -20 °C. Following reconstitution it is stable for two weeks at 2-8 °C. Frozen aliquots are stable for 6 months when stored at -20 °C.
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有效期
- 6 months
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- IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))
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别名
- IGFBP5
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背景
- IGFBP5 is one of a family of proteins that bind to insulin-like growth factors (IGFs). IGFBP5 is a multifunctional protein which acts not only as a traditional binding protein but also functions as a growth factor independent of IGFs to stimulate bone formation. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGFII. IGFBP5 is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGFI on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development.Synonyms: IBP-5, IBP5, IGF-binding protein 5, IGFBP-5, Insulin-like growth factor-binding protein 5
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基因ID
- 3488
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NCBI登录号
- NP_000590
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UniProt
- P24593
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途径
- WNT signaling, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
抗原
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