(2 references)-
- 抗原 See all IGFBP5 抗体
- IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))
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抗原表位
- AA 76-114, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IGFBP5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 原理
- Rabbit IgG polyclonal antibody for Insulin-like growth factor-binding protein 5(IGFBP5) detection. Tested with WB, ELISA in Human.
- 序列
- QGLRCLPRQD EEKPLHALLH GRGVCLNEKS YREQVKIER
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
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Rabbit IgG polyclonal antibody for Insulin-like growth factor-binding protein 5(IGFBP5) detection. Tested with WB, ELISA in Human.
Gene Name: insulin-like growth factor binding protein 5
Protein Name: Insulin-like growth factor-binding protein 5 - 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human IGFBP5 (76-114aa QGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIER), different from the related mouse and rat sequences by two amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product IGFBP5 Primary Antibody
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anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 68-167) antibody
IGFBP5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) antibodyIGFBP5 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 25-271) antibodyIGFBP5 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) antibodyIGFBP5 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) antibodyIGFBP5 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 21-272) antibodyIGFBP5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 101-200) antibodyIGFBP5 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 27-248) antibodyIGFBP5 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 27-248) antibodyIGFBP5 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D4 unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 87-121) antibodyIGFBP5 适用: 人 WB 宿主: 兔 Polyclonal RB54635 unconjugated
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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: "The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells." in: Journal of experimental & clinical cancer research : CR, Vol. 28, pp. 150, (2010) (PubMed).
: "Expressions of IGFBP-5, cFLIP in cervical intraepithelial neoplasia, cervical carcinoma and their clinical significances: a molecular pathology." in: Journal of experimental & clinical cancer research : CR, Vol. 28, pp. 70, (2009) (PubMed).
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: "The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells." in: Journal of experimental & clinical cancer research : CR, Vol. 28, pp. 150, (2010) (PubMed).
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- 抗原
- IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))
- 别名
- IGFBP5 (IGFBP5 产品)
- 别名
- IBP5 antibody, AI256729 antibody, AW208790 antibody, IGFBP-5 antibody, IGFBP-5P antibody, IGF-BP5 antibody, igfbp5 antibody, ibp5 antibody, IBP-5 antibody, xIGFBP-5 antibody, IGFBP5 antibody, igfbp5b antibody, zgc:165472 antibody, insulin like growth factor binding protein 5 antibody, insulin-like growth factor binding protein 5 antibody, insulin like growth factor binding protein 5 L homeolog antibody, insulin-like growth factor binding protein 5b antibody, insulin-like growth factor-binding protein 5 antibody, insulin-like growth factor binding protein 5a antibody, IGFBP5 antibody, Igfbp5 antibody, igfbp5.L antibody, igfbp5b antibody, igfbp5 antibody, LOC100194500 antibody, igfbp5a antibody
- 背景
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Insulin-like growth factor-binding protein 5 is a protein that in humans is encoded by the IGFBP5 gene. The expression of IGFBP5 by stable transfection and adenovirus-mediated infection is inhibitory to growth in 2 human breast cancer cell lines. IGFBP5 expression leads to G2/M cell cycle arrest and apoptosis. Stable expression of IGFBP5 in the breast cancer cell lines also inhibits the formation and growth of tumors following injection in athymic mice. It is concluded that IGFBP5 is a growth inhibitor and proapoptotic agent in breast cancer cells. Additionally, IGFBP-5 is expressed by fibroblasts, myoblasts and osteoblasts, making it the predominant IGFBP found in bone extracts. It has a strong affinity for hydroxyapatite, allowing it to bind to bone cells. When bound to extracellular matrix, IGFBP-5 is protected from proteolysis and potentiates IGF activity, but when it is soluble, IGFBP-5 is cleaved to a biologically inactive 21 kDa fragment (1, 2).
Synonyms: IBP 5 antibody|IBP-5 antibody|IBP5 antibody|IBP5_HUMAN antibody|IGF binding protein 5 antibody|IGF BP5 antibody|IGF-binding protein 5 antibody|IGFBP 5 antibody|IGFBP-5 antibody|IGFBP5 antibody|Insulin like growth factor binding protein 5 antibody|Insulin-like growth factor-binding protein 5 antibody - 基因ID
- 3488
- UniProt
- P24593
- 途径
- WNT signaling, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
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