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Nibrin 抗体 (AA 467-615)

This anti-Nibrin antibody is a 小鼠 单克隆 antibody detecting Nibrin in WB, ELISA, IHC, ICC 和 FACS. Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN1724942
发货至: 中国

Quick Overview for Nibrin 抗体 (AA 467-615) (ABIN1724942)

抗原

See all Nibrin (NBN) 抗体
Nibrin (NBN)

适用

  • 94
  • 61
  • 35
  • 2
  • 1
  • 1
  • 1
  • 1

宿主

  • 112
  • 14
小鼠

克隆类型

  • 99
  • 27
单克隆

标记

  • 69
  • 7
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
This Nibrin antibody is un-conjugated

应用范围

  • 104
  • 41
  • 31
  • 28
  • 27
  • 26
  • 22
  • 15
  • 14
  • 12
  • 6
  • 4
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

克隆位点

7E4C2
  • 抗原表位

    • 39
    • 15
    • 10
    • 8
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 467-615

    原理

    NBN Antibody

    纯化方法

    Purified antibody

    免疫原

    Purified recombinant fragment of human NBN (AA: 467-615) expressed in E. Coli.

    亚型

    IgG2a
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/200 - 1/1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified antibody in PBS with 0.05 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Zuhlke, Johnson, Okoth, Stoffel, Robbins, Tembe, Salinas, Zheng, Xu, Carpten, Lange, Isaacs, Cooney: "Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer." in: Familial cancer, Vol. 11, Issue 4, pp. 595-600, (2012) (PubMed).

    Zheng, Zhang, Jiang, You, Liu, Lu, Zhou: "Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma." in: Molecular carcinogenesis, Vol. 50, Issue 9, pp. 689-96, (2011) (PubMed).

  • 抗原

    Nibrin (NBN)

    别名

    NBN

    背景

    Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

    分子量

    85 kDa

    基因ID

    4683

    UniProt

    O60934

    途径

    DNA Damage Repair, Production of Molecular Mediator of Immune Response
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