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PCNA 抗体 (AA 53-196)

This anti-PCNA antibody is a 小鼠 单克隆 antibody detecting PCNA in WB, IHC, ELISA 和 FACS. Suitable for 人 和 猴. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN1724759
发货至: 中国

Quick Overview for PCNA 抗体 (AA 53-196) (ABIN1724759)

抗原

See all PCNA 抗体
PCNA (Proliferating Cell Nuclear Antigen (PCNA))

适用

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人, 猴

宿主

  • 143
  • 111
  • 3
小鼠

克隆类型

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  • 116
  • 1
单克隆

标记

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This PCNA antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

克隆位点

7H4F8
  • 抗原表位

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    AA 53-196

    原理

    PCNA Antibody

    纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human PCNA (AA: 53-196 ) expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Ascitic fluid containing 0.03 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Takawa, Cho, Hayami, Toyokawa, Kogure, Yamane, Iwai, Maejima, Ueda, Masuda, Dohmae, Field, Tsunoda, Kobayashi, Akasu, Sugiyama, Ohnuma, Atomi, Ponder, Nakamura, Hamamoto: "Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression." in: Cancer research, Vol. 72, Issue 13, pp. 3217-27, (2012) (PubMed).

    Zhao, Ho, Lo, Espejo, Bedford, Hung, Wang: "Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer." in: PLoS ONE, Vol. 7, Issue 1, pp. e29416, (2012) (PubMed).

  • 抗原

    PCNA (Proliferating Cell Nuclear Antigen (PCNA))

    别名

    PCNA

    背景

    The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

    分子量

    28.7 kDa

    基因ID

    5111

    UniProt

    P12004

    途径

    Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy
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