ATM 抗体 (full length)
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北京 101111
Quick Overview for ATM 抗体 (full length) (ABIN1721458)
抗原
See all ATM 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 2577-3056, full length
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特异性
- Reacts with human ATM. Cross-reacts with mouse, rat and monkey protein.
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纯化方法
- Purified
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免疫原
- GST fusion protein expressed in E. coli corresponding to aa 2577- 3056 of full-length ATM.
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亚型
- IgG1 kappa
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应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB1:500 - 1:3000 IHC-P5 μg/mL IP1 - 10 μg/mL. -
限制
- 仅限研究用
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缓冲液
- PBS, pH 7.4
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注意事项
- Dilute in PBS or medium that is identical to that used in the assay system.
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储存条件
- -20 °C/-80 °C
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储存方法
- Stable for at least one year at -20°C or -70°C. Avoid multiple freeze-thaw cycles.
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有效期
- 12 months
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- ATM (Ataxia Telangiectasia Mutated (ATM))
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别名
- ATM
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背景
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ATM is a 370 kD nuclear phosphoprotein,which is involved in the autooal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigations.
Serine-protein kinase ATM Ataxia telangiectasia mutated, A-T mutated gene name: ATM AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 -
基因ID
- 472
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UniProt
- Q13315
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途径
- p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
抗原
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