AFT1 抗体 (pSer63) (Alexa Fluor 350)
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- 抗原 See all AFT1 抗体
- AFT1 (Activating Transcription Factor 1 (AFT1))
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抗原表位
- pSer63
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This AFT1 antibody is conjugated to Alexa Fluor 350
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Pig,Horse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human ATF1 around the phosphorylation site of Ser63
- 亚型
- IgG
- Top Product
- Discover our top product AFT1 Primary Antibody
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anti-Activating Transcription Factor 1 (AFT1) (AA 1-271) antibody
AFT1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 1 (AFT1) (AA 1-271) antibodyAFT1 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3E7 unconjugated
anti-Activating Transcription Factor 1 (AFT1) (AA 3-245) antibodyAFT1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 1 (AFT1) (Internal Region) antibodyAFT1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 1 (AFT1) (AA 1-271) antibodyAFT1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Activating Transcription Factor 1 (AFT1) (C-Term) antibodyAFT1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 1 (AFT1) (AA 3-213) antibodyAFT1 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 1 (AFT1) (AA 1-210) antibodyAFT1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 1 (AFT1) (Ser157) antibodyAFT1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 1 (AFT1) (C-Term) antibodyAFT1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- AFT1 (Activating Transcription Factor 1 (AFT1))
- 别名
- ATF1 (AFT1 产品)
- 别名
- ews-atf1 antibody, fus/atf-1 antibody, treb36 antibody, ATF1 antibody, EWS-ATF1 antibody, FUS/ATF-1 antibody, TREB36 antibody, Atf-1 antibody, wu:fc92c07 antibody, zgc:64099 antibody, activating transcription factor 1 antibody, activating transcription factor 1 L homeolog antibody, atf1 antibody, ATF1 antibody, MGC85066 antibody, atf1.L antibody, Atf1 antibody
- 背景
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Synonyms: ATF1 phospho S63, p-ATF1 phospho S63, Activating Transcription Factor1, TREB36 protein, ATF 1, ATF1 EWS fusion gene ATF1 FUS fusion gene, cAMP dependent transcription factor 1, Cyclic AMP dependent transcription factor ATF 1, Cyclic AMP dependent transcription factor ATF1, EWS AFT1, FUS ATF 1, RNA binding protein activating transcription factor 1 fusion protein, TREB 36, TREB36.
Background: ATF1 (Activating Transcription Factor 1, TREB-36) is a member of the ATF/CREB family of basic region leucine-zipper (bZip) DNA-binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. The activation function of CRE-binding proteins may be modulated by phosphorylation of several kinases and is mediated by coactivators such as CREB-binding protein (CBP) and p300. ATF1 is a nuclear protein that binds DNA as a homodimer or as heterodimers with the inducible transcription factors CREB1 or CREM. Heterodimers appear to be stronger transcriptional activators than the homodimers. Tissue expression of ATF1 mRNA is widespread. Several isoforms of ATF1 arise by differential splicing. ATF1 mediates both Ca2+ and cAMP responses at several levels. It binds to the Tax-responsive element (TRE1) of the human T-cell lymphotropic virus type-I (HTLV1). ATF1 is detectable in metastatic melanoma cells and seems to contribute to their survival. A chimeric protein composed of the N-terminal domain of EWS (Ewing sarcoma oncogene) linked to the bZip domain of ATF1 is implicated in the rare malignant clear cell sarcoma of tendon sheath and aponeuroses (malignant melanoma of soft parts).
- 基因ID
- 466
- 途径
- Neurotrophin Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades
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