The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],HTRP-1, TRP1,Calcium Signaling,Cardiovascular,Heart,Heart_Hypertrophy,Neuroscience,Signal Transduction,TRPC1