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LRP2 抗体 (AA 4446-4655)

This anti-LRP2 antibody is a 兔 多克隆 antibody detecting LRP2 in IHC 和 WB. Suitable for 人.
产品编号 ABIN1680712
发货至: 中国

Quick Overview for LRP2 抗体 (AA 4446-4655) (ABIN1680712)

抗原

See all LRP2 抗体
LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

适用

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宿主

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克隆类型

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多克隆

标记

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This LRP2 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Western Blotting (WB)
  • 抗原表位

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    AA 4446-4655

    序列

    FHYRRTGSLL PALPKLPSLS SLVKPSENGN GVTFRSGADL NMDIGVSGFG PETAIDRSMA MSEDFVMEMG KQPIIFENPM YSARDSAVKV VQPIQVTVSE NVDNKNYGSP INPSEIVPET NPTSPAADGT QVTKWNLFKR KSKQTTNFEN PIYAQMENEQ KESVAATPPP SPSLPAKPKP PSRRDPTPTY SATEDTFKDT ANLVKEDSEV

    交叉反应

    小鼠, 大鼠

    产品特性

    Polyclonal Antibodies

    免疫原

    Recombinant fusion protein containing a sequence corresponding to amino acids 4446-4655 of human LRP2 (NP_004516.2).

    亚型

    IgG
  • 应用备注

    WB,1:200 - 1:1000,IHC,1:20 - 1:100

    限制

    仅限研究用
  • 缓冲液

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

    别名

    LRP2

    背景

    The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling, extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).,LRP2,DBS,GP330,Cancer,Cell Biology & Developmental Biology,Endocrine & Metabolism,Lipid Metabolism,Endocrine and metabolic diseases,Obesity,Stem Cells,Cardiovascular,Lipids,Fatty Acids,LRP2

    分子量

    521 kDa

    基因ID

    4036

    UniProt

    P98164

    途径

    Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport
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