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SNCA 抗体

SNCA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5C2 unconjugated
产品编号 ABIN361093
发货至: 中国
  • 抗原 See all SNCA 抗体
    SNCA (Synuclein, alpha (SNCA))
    适用
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    小鼠
    克隆类型
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    单克隆
    标记
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    This SNCA antibody is un-conjugated
    应用范围
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    Western Blotting (WB), ELISA
    纯化方法
    The antibody was purified from mouse ascitic fluids by protein-G affinity chromatography
    免疫原
    Recombinant human alpha-synuclein (61-95) purified from E. coli. NCBI Accession No.: NP_000336.
    克隆位点
    5C2
    亚型
    IgG1
    Top Product
    Discover our top product SNCA Primary Antibody
  • 应用备注
    The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1:2,000. This antibody (5C2) has the specificity against the NAC domain (61-95aa) of alpha-synuclein. Recommended starting dilution is 1:1,000.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/ml
    缓冲液
    Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • 抗原
    SNCA (Synuclein, alpha (SNCA))
    别名
    A-Synuclein (SNCA 产品)
    别名
    snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody
    背景
    Alpha-synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. a-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-Abeta component of amyloid plaques (NAC, amino acids 61-95) is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain. Clone: Anti-human alpha-Synuclein mAb, clone 5C2, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human alpha-synuclein protein. This antibody specifically recognizes alpha-synuclein only, particularly the NAC domain of alpha-synuclein.
    途径
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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