Western Blot: 0.5-4 μg/mL. A549 or HepG2 cell lysate can be used as a positive control. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
AAP1 antibody, DEDAF antibody, YEAF1 antibody, 2410018J24Rik antibody, rybp antibody, aap1 antibody, dedaf antibody, yeaf1 antibody, cb337 antibody, wu:fi34f03 antibody, Dedaf antibody, zgc:153842 antibody, RING1 and YY1 binding protein antibody, RING1 and YY1 binding protein L homeolog antibody, RING1 and YY1 binding protein a antibody, RING1 and YY1 binding protein b antibody, RYBP antibody, Rybp antibody, rybp antibody, rybp.L antibody, rybpa antibody, rybpb antibody
背景
Cell death signal are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. A novel protein that interacts with DED of caspase-8 and -10, and FADD was recently identified and designated DEDAF (for DED associated factor). DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/caspase-8 complexes at the cytoplasm. DEDAF also interacts with DED-containing DNA biding protein (DEDD) in the nucleus, indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.Synonyms: AAP-1, APAP-1, Apoptin-associating protein 1, DED-associated factor, DEDAF, Death effector domain-associated factor, RING1 and YY1-binding protein, YEAF1, YY1 and E4TF1-associated factor 1