RYBP 抗体
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北京 101111
Quick Overview for RYBP 抗体 (ABIN155069)
抗原
See all RYBP 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects DEDAF. A 32 kDa band should be detected.
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纯化方法
- Affinity purified
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免疫原
- Synthetic peptide surrounding amino acid 218 of human DEDAF.
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应用备注
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Western Blot: 0.5-4 μg/mL. A549 or HepG2 cell lysate can be used as a positive control.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C/-80 °C
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储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
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- RYBP (RING1 and YY1 Binding Protein (RYBP))
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别名
- RYBP
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背景
- Cell death signal are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. A novel protein that interacts with DED of caspase-8 and -10, and FADD was recently identified and designated DEDAF (for DED associated factor). DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/caspase-8 complexes at the cytoplasm. DEDAF also interacts with DED-containing DNA biding protein (DEDD) in the nucleus, indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.Synonyms: AAP-1, APAP-1, Apoptin-associating protein 1, DED-associated factor, DEDAF, Death effector domain-associated factor, RING1 and YY1-binding protein, YEAF1, YY1 and E4TF1-associated factor 1
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基因ID
- 23429
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NCBI登录号
- NP_036366
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UniProt
- Q8N488
抗原
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