AKT1 抗体 (AA 292-341)
Our Local Distributor
北京 101111
Quick Overview for AKT1 抗体 (AA 292-341) (ABIN1532536)
抗原
See all AKT1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 292-341
-
原理
- Akt Antibody
-
特异性
- Akt Polyclonal Antibody detects endogenous levels of Akt protein.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
纯度
- > 95 %
-
免疫原
- The antiserum was produced against synthesized peptide derived from human Akt. AA range:292-341
-
亚型
- IgG
-
-
-
-
应用备注
- Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C/1 year
-
有效期
- 12 months
-
-
- AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
-
别名
- Akt
-
背景
-
Synonyms: AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha
Background: G protein-coupled receptor kinase 2(GRK2) Homo sapiens The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],
Gene Name: AKT1/AKT2/AKT3
Protein Name: RAC-alpha serine/threonine-protein kinase
-
分子量
- 55 kDa
-
OMIM
- 164730
-
UniProt
- P31749
-
途径
- PI3K-Akt Signaling, RTK signaling, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Water Deprivation, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGFR1 Specific Signals, VEGF Signaling, Warburg Effect
抗原
-