V-Akt Murine Thymoma Viral Oncogene Homolog 1 抗体
(V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011].
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Rockland Original
Latest Publications for our V-Akt Murine Thymoma Viral Oncogene Homolog 1 抗体
: "Enforced expression of miR-92b blunts E. coli lipopolysaccharide-mediated inflammatory injury by activating the PI3K/AKT/β-catenin pathway via targeting PTEN." in: International journal of biological sciences, Vol. 17, Issue 5, pp. 1289-1301, (2022) (PubMed).
: "ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer." in: Aging, Vol. 12, Issue 10, pp. 9915-9934, (2021) (PubMed).
: "SQSTM1/p62 Promotes Cell Growth and Triggers Autophagy in Papillary Thyroid Cancer by Regulating the AKT/AMPK/mTOR Signaling Pathway." in: Frontiers in oncology, Vol. 11, pp. 638701, (2021) (PubMed).
: "Shaoyao-Gancao Decoction Ameliorates the Inflammation State in Polycystic Ovary Syndrome Rats via Remodeling Gut Microbiota and Suppressing the TLR4/NF-κB Pathway." in: Frontiers in pharmacology, Vol. 12, pp. 670054, (2021) (PubMed).
: "8-Gingerol Ameliorates Myocardial Fibrosis by Attenuating Reactive Oxygen Species, Apoptosis, and Autophagy via the PI3K/Akt/mTOR Signaling Pathway." in: Frontiers in pharmacology, Vol. 12, pp. 711701, (2021) (PubMed).
: "The neuronal receptor tyrosine kinase Alk is a target for longevity." in: Aging cell, Vol. 19, Issue 5, pp. e13137, (2020) (PubMed).
: "PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism." in: BMC molecular biology, Vol. 20, Issue 1, pp. 24, (2020) (PubMed).
: "Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NF-κB expression." in: Bioscience reports, Vol. 39, Issue 6, (2020) (PubMed).
: "Woodchuck VEGF (wVEGF) characteristics: Model for angiogenesis and human hepatocellular carcinoma directed therapies." in: Archives of biochemistry and biophysics, Vol. 661, pp. 97-106, (2019) (PubMed).
: "A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer." in: Pharmacological research, Vol. 129, pp. 500-514, (2019) (PubMed).
: "ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer." in: Aging, Vol. 12, Issue 10, pp. 9915-9934, (2021) (PubMed).
: "SQSTM1/p62 Promotes Cell Growth and Triggers Autophagy in Papillary Thyroid Cancer by Regulating the AKT/AMPK/mTOR Signaling Pathway." in: Frontiers in oncology, Vol. 11, pp. 638701, (2021) (PubMed).
: "Shaoyao-Gancao Decoction Ameliorates the Inflammation State in Polycystic Ovary Syndrome Rats via Remodeling Gut Microbiota and Suppressing the TLR4/NF-κB Pathway." in: Frontiers in pharmacology, Vol. 12, pp. 670054, (2021) (PubMed).
: "8-Gingerol Ameliorates Myocardial Fibrosis by Attenuating Reactive Oxygen Species, Apoptosis, and Autophagy via the PI3K/Akt/mTOR Signaling Pathway." in: Frontiers in pharmacology, Vol. 12, pp. 711701, (2021) (PubMed).
: "The neuronal receptor tyrosine kinase Alk is a target for longevity." in: Aging cell, Vol. 19, Issue 5, pp. e13137, (2020) (PubMed).
: "PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism." in: BMC molecular biology, Vol. 20, Issue 1, pp. 24, (2020) (PubMed).
: "Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NF-κB expression." in: Bioscience reports, Vol. 39, Issue 6, (2020) (PubMed).
: "Woodchuck VEGF (wVEGF) characteristics: Model for angiogenesis and human hepatocellular carcinoma directed therapies." in: Archives of biochemistry and biophysics, Vol. 661, pp. 97-106, (2019) (PubMed).
: "A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer." in: Pharmacological research, Vol. 129, pp. 500-514, (2019) (PubMed).
Aliases for V-Akt Murine Thymoma Viral Oncogene Homolog 1 抗体
AKT serine/threonine kinase 1 (AKT1) 抗体thymoma viral proto-oncogene 1 (Akt1) 抗体
protein tyrosine kinase 2 beta (PTK2B) 抗体
CG4006 gene product from transcript CG4006-RE (Akt1) 抗体
actin beta (ACTB) 抗体
AKT serine/threonine kinase 1 (Akt1) 抗体
v-akt murine thymoma viral oncogene homolog 1 S homeolog (akt1.S) 抗体
v-akt murine thymoma viral oncogene homolog 1 (akt1) 抗体
AKT serine/threonine kinase 1 (akt1) 抗体
K+ transporter 1 (KT1) 抗体
Serine/threonine-protein kinase akt-1 (akt-1) 抗体
ACT-5 抗体
AKT 抗体
Akt 抗体
akt 抗体
akt-1 抗体
AKT/PKB 抗体
Akt/PKB 抗体
AKT1 抗体
Akt1 抗体
akt1 抗体
ATAKT1 抗体
CADTK 抗体
CAKB 抗体
CG4006 抗体
CWS6 抗体
D-Akt 抗体
DAkt 抗体
Dakt 抗体
dAKT 抗体
dAkt 抗体
dakt 抗体
dAKT/dPKB 抗体
dAkt/PKB 抗体
DAKT1 抗体
DAkt1 抗体
Dakt1 抗体
dAKT1 抗体
dAkt1 抗体
dakt1 抗体
DAKT1/PKB 抗体
Dmel\\CG4006 抗体
DPKB 抗体
Dpkb 抗体
dPKB 抗体
DRAC-PK 抗体
DRAC-PK66 抗体
DRAC-PK85 抗体
F18A8.2 抗体
F18A8_2 抗体
FADK2 抗体
FAK2 抗体
K+ transporter 1 抗体
l(3)04226 抗体
l(3)89Bq 抗体
p-Akt 抗体
pAkt 抗体
PKB 抗体
pkb 抗体
PKB-ALPHA 抗体
PKB/Akt 抗体
PKB/AKT 抗体
PKB/dAKT 抗体
PKBalpha 抗体
POTASSIUM TRANSPORTER 抗体
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PTK 抗体
PYK2 抗体
RAC 抗体
Rac 抗体
RAC-ALPHA 抗体
RacPK 抗体
RAFTK 抗体
v-akt 抗体
v-akt1 抗体
xAct 抗体
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