TLK1 抗体 (AA 730-779)
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北京 101111
Quick Overview for TLK1 抗体 (AA 730-779) (ABIN1532489)
抗原
See all TLK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 730-779
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原理
- TLK1 Antibody
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特异性
- TLK1 Polyclonal Antibody detects endogenous levels of TLK1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human TLK1. AA range:730-779
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亚型
- IgG
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anti-Tousled-Like Kinase 1 (TLK1) (AA 720-750), (C-Term) antibody
TLK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3043 unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 160-230) antibodyTLK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) antibodyTLK1 适用: 人 WB, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 111-230) antibodyTLK1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4B3 unconjugated
anti-Tousled-Like Kinase 1 (TLK1) antibodyTLK1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 458-560) antibodyTLK1 适用: 人 WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 701-728), (C-Term) antibodyTLK1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB37154 unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 730-779) antibodyTLK1 适用: 人, 小鼠 ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 251-300) antibodyTLK1 适用: 人, 小鼠, 大鼠, 猴, 犬, 马, 兔, Cow, Pig, 斑马鱼, 豚鼠, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 108-157) antibodyTLK1 适用: 人, 猴, 犬, 马, 兔, Cow, Pig, 斑马鱼, Bat WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- TLK1 (Tousled-Like Kinase 1 (TLK1))
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别名
- TLK1
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背景
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Synonyms: TLK1, KIAA0137, Serine/threonine-protein kinase tousled-like 1, PKU-beta, Tousled-like kinase 1
Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation at Ser-743, potentially by CHK1.,function:Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.,tissue specificity:Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.,
Gene Name: TLK1
Protein Name: Serine/threonine-protein kinase tousled-like 1
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分子量
- 86 kDa
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基因ID
- 9874
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OMIM
- 608438
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UniProt
- Q9UKI8
抗原
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