PIM1 抗体 (pTyr309)
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Quick Overview for PIM1 抗体 (pTyr309) (ABIN1531460)
抗原
See all PIM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 281-330, pTyr309
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原理
- Pim-1 (phospho Tyr309) Antibody
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特异性
- Phospho-Pim-1 (Y309) Polyclonal Antibody detects endogenous levels of Pim-1 protein only when phosphorylated at Y309.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human Pim-1 around the phosphorylation site of Tyr309. AA range:281-330
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- PIM1 (Pim-1 Oncogene (PIM1))
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别名
- Pim-1
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背景
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Synonyms: PIM1, Serine/threonine-protein kinase pim-1
Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011],
Gene Name: PIM1
Protein Name: Serine/threonine-protein kinase pim-1
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分子量
- 45 kDa
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基因ID
- 5292
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OMIM
- 164960
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UniProt
- P11309
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途径
- Glycosaminoglycan Metabolic Process
抗原
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