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HLA-DR 抗体

Cited in 10+ publications. The 小鼠 单克隆 anti-HLA-DR antibody (Clone L243) (ABIN1526070) specifically detects HLA-DR in FACS, WB, IP, IF, IHC (p), IHC (fro) 和 Func. The antibody is reactive with 人, 犬 和 灵长类 samples.
Pubmed (10 references)
产品编号 ABIN1526070
发货至: 中国
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Our Local Distributor

中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for HLA-DR 抗体 (ABIN1526070)

抗原

HLA-DR

适用

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人, 犬, 灵长类

宿主

  • 118
  • 36
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小鼠

克隆类型

  • 159
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单克隆

标记

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This HLA-DR antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

克隆位点

L243

  • 交叉反应 （详细）

    Species reactivity (tested):Human, Non-Human Primates, Canine (Dog)

    纯化方法

    Protein-A affinity chromatography

    亚型

    IgG2a
  • anti-HLA-DR (HLA-DR) antibody
    anti-HLA-DR (HLA-DR) antibody

    HLA-DR 适用: 人 FACS, WB, IHC, ICC, IF (p) 宿主: 小鼠 Monoclonal LN3 unconjugated

    anti-HLA-DR (HLA-DR) antibody
    anti-HLA-DR (HLA-DR) antibody

    HLA-DR 适用: 人 FACS, WB, IHC 宿主: 小鼠 Monoclonal TAL 1B5 unconjugated

    anti-HLA-DR (HLA-DR) antibody (FITC)
    anti-HLA-DR (HLA-DR) antibody (FITC)

    HLA-DR 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-12 FITC

    anti-HLA-DR (HLA-DR) antibody
    anti-HLA-DR (HLA-DR) antibody

    HLA-DR 适用: 人, 猴 FACS, WB, IHC, IF 宿主: 小鼠 Monoclonal SPM289 unconjugated

    anti-HLA-DR (HLA-DR) antibody
    anti-HLA-DR (HLA-DR) antibody

    HLA-DR 适用: 人, 犬, Non-Human Primate FACS, WB, IP, IHC (p), IHC (fro), ICC 宿主: 小鼠 Monoclonal L243 unconjugated

    anti-HLA-DR (HLA-DR) antibody (PE)
    anti-HLA-DR (HLA-DR) antibody (PE)

    HLA-DR 适用: 人, 犬, Non-Human Primate FACS 宿主: 小鼠 Monoclonal L243 PE

    anti-HLA-DR (HLA-DR) antibody
    anti-HLA-DR (HLA-DR) antibody

    HLA-DR 适用: 人 FACS, WB, IP 宿主: 小鼠 Monoclonal MEM-12 unconjugated

    anti-HLA-DR (HLA-DR) antibody
    anti-HLA-DR (HLA-DR) antibody

    HLA-DR 适用: 人, 犬, Non-Human Primate FACS, WB, IP, IHC (p), IHC (fro), ICC, Func 宿主: 小鼠 Monoclonal L243 unconjugated

    anti-HLA-DR (HLA-DR) antibody (PerCP)
    anti-HLA-DR (HLA-DR) antibody (PerCP)

    HLA-DR 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-12 PerCP

    anti-HLA-DR (HLA-DR) antibody (APC)
    anti-HLA-DR (HLA-DR) antibody (APC)

    HLA-DR 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-12 APC

  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用

  • 浓度

    1.0 mg/mL

    缓冲液

    PBS, pH ~7.4, 15 mM Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Ezoe, Daikoku, Yabuuchi, Murata, Kawano, Abe, Okuno, Kobayashi, Kato: "Ovarian stimulation using human chorionic gonadotrophin impairs blastocyst implantation and decidualization by altering ovarian hormone levels and downstream signaling in mice." in: Molecular human reproduction, Vol. 20, Issue 11, pp. 1101-16, (2015) (PubMed).

    Ivanov, Beers, Walshe, Honeychurch, Alduaij, Cox, Potter, Murray, Chan, Klymenko, Erenpreisa, Glennie, Illidge, Cragg: "Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells." in: The Journal of clinical investigation, Vol. 119, Issue 8, pp. 2143-59, (2009) (PubMed).

    De Gassart, Camosseto, Thibodeau, Ceppi, Catalan, Pierre, Gatti: "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 9, pp. 3491-6, (2008) (PubMed).

    Swiatek-de Lange, Rist, Stahl, Weith, Lenter: "Comment on "MHC class II expression identifies functionally distinct human regulatory T cells"." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 6, pp. 3625; author reply 3626, (2008) (PubMed).

    Bouillon, El Fakhry, Girouard, Khalil, Thibodeau, Mourad: "Lipid raft-dependent and -independent signaling through HLA-DR molecules." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7099-107, (2003) (PubMed).

    Muczynski, Ekle, Coder, Anderson: "Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression." in: Journal of the American Society of Nephrology : JASN, Vol. 14, Issue 5, pp. 1336-48, (2003) (PubMed).

    Kalka-Moll, Tzianabos, Bryant, Niemeyer, Ploegh, Kasper: "Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 11, pp. 6149-53, (2002) (PubMed).

    Cantin, Martin, Tremblay et al.: "A novel virus capture assay reveals a differential acquisition of host HLA-DR by clinical isolates of human immunodeficiency virus type 1 expanded in primary human cells depending on the nature of ..." in: The Journal of general virology, Vol. 82, Issue Pt 12, pp. 2979-87, (2001) (PubMed).

    Schmitz, Weissenbach, Haan, Heinrich, Schaper: "SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130." in: The Journal of biological chemistry, Vol. 275, Issue 17, pp. 12848-56, (2000) (PubMed).

    Gabbert, Mueller, Schneiders, Meier, Moll, Birchmeier, Hommel: "Prognostic value of E-cadherin expression in 413 gastric carcinomas." in: International journal of cancer. Journal international du cancer, Vol. 69, Issue 3, pp. 184-9, (1996) (PubMed).

  • 抗原

    HLA-DR

    别名

    HLA Class II DR

    背景

    HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system. It is expressed on antigen-presenting cells (dendritic cells, B lymphocytes, monocytes, macrophages).Synonyms: HLA class II histocompatibility antigen DR, HLA-DR, MHC class II antigen DR

    途径

    Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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