5730408I21Rik antibody, SQV7L antibody, UGTrel8 antibody, hfrc antibody, mUGTrel8 antibody, solute carrier family 35, member D2 antibody, Slc35d2 antibody
背景
The solute carrier family SLC35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident SLC family member SLC35D2 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. Its overexpression in transfected cells modulated cell surface heparin sulfate expression, suggesting that SLC35D2 is involved in heparin sulfate synthesis. SLC35D2-overexpressing cells also showed increased constitutive and hypotonic stress-stimulated release of UDP-GlcNAc, suggesting that SLC35D2 may be involved in UDP-sugar release and cell signaling.Synonyms: HFRC, HFRC1, Homolog of Fringe connection protein 1, SQV7-like protein, SQV7L, Solute carrier family 35 member D2, UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter, UDP-galactose transporter-related protein 8