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Quick Overview for ATR 抗体 (ABIN1449281)
抗原
See all ATR 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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序列
- CPCELEHSIK PLFQHSPGDS SQED
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特异性
- This antibody reacts with human ATR.
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纯化方法
- Protein A agarose
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免疫原
- Carrier protein (CP) conjugated synthetic peptide
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亚型
- IgG1
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anti-Ataxia Telangiectasia and Rad3 Related (ATR) (AA 2353-2644) antibody
ATR 适用: 人 WB, IP, ICC, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ataxia Telangiectasia and Rad3 Related (ATR) (Ser428) antibodyATR 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ataxia Telangiectasia and Rad3 Related (ATR) (Internal Region) antibodyATR 适用: 人, 小鼠, 犬, 鱼, 猴, 大鼠, 非洲爪蟾 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Upon receipt, store (in aliqouts) at -20 °C.
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- ATR (Ataxia Telangiectasia and Rad3 Related (ATR))
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别名
- ATR / FRP1
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背景
- ATR (ataxia telangiectasia and Rad-3-related) is one of the most important checkpoint proteins in mammalian cells responding to DNA damage. ATR is a member of the phosphatidylinositol kinase-related protein family that includes ATM (ataxia telangiectasia mutated). These kinases are essential for signaling the presence of DNA damage or replication blocks and activating cell cycle checkpoints. It is reported that checkpoint kinase 1 (CHK1), RAD9, RAD17, Histone H2AX, p53, and BRCA1 are phosphorylated in response to genotoxic stress in an ATR-dependent manner. ATR also phosphorylates ATR-interacting protein (ATRIP) that regulates ATR expression, and is an essential component of the DNA damage checkpoint signaling pathways. In addition, homozygous deletion of ATR in mice causes early embryonic lethality, suggesting that ATR has essential functions during development.Synonyms: Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, Serine/threonine-protein kinase ATR
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基因ID
- 545
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NCBI登录号
- NP_001175
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UniProt
- Q13535
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途径
- p53 Pathway, Apoptosis, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
抗原
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