ANKRD13B 抗体 (Cy5.5)
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- 抗原 See all ANKRD13B products
- ANKRD13B (Ankyrin Repeat Domain 13B (ANKRD13B))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ANKRD13B antibody is conjugated to Cy5.5
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应用范围
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human ANKRD13B
- 亚型
- IgG
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anti-Ankyrin Repeat Domain 13B (ANKRD13B) (AA 540-589) antibody
ANKRD13B 适用: 人, 小鼠, 大鼠, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ankyrin Repeat Domain 13B (ANKRD13B) (Middle Region) antibodyANKRD13B 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- IF(IHC-P) 1:50-200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- ANKRD13B (Ankyrin Repeat Domain 13B (ANKRD13B))
- 别名
- ANKRD13B (ANKRD13B 产品)
- 别名
- zgc:113371 antibody, AW124583 antibody, B930093C12Rik antibody, RGD1564005 antibody, ankyrin repeat domain 13B antibody, ankyrin repeat domain 13B L homeolog antibody, ankyrin repeat domain 13b antibody, ANKRD13B antibody, ankrd13b antibody, ankrd13b.L antibody, Ankrd13b antibody
- 背景
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Synonyms: Ankrd13b, ANKRD13Bankyrin repeat domain 13B, ankyrin repeat domain 13B, AN13B_HUMAN.
Background: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes can lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD13B (ankyrin repeat domain 13B) is a 626 amino acid protein that contains two ANK repeats and three ubiquitin-interacting motif (UIM) repeats. Conserved in dog, cow, mouse and rat, ANKRD13B exists as two alternatively spliced isoforms. The gene that encodes ANKRD13B maps to human chromosome 17, which makes up over 2.5 % of the human genome, with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. BRCA1 is recognized as a genetic determinant of early onset breast cancer. Chromosome 17 is also linked to neurofibromatosis, dysregulated Schwann cell growth, Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease.
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